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Conference Highlights -  Apr 21, 2012 | Day Three
Late Breaking News

DAY 3 HIGHLIGHTS

In AMI patients undergoing PCI, hyperglycemia is associated with an increased risk for contrast-induced nephropathy.

Treatment with the direct thrombin inhibitor bivalirudin in prolonged infusion >120 minutes in patients undergoing PCI does not increase risk of bleeding complications.

Despite higher caloric intake and saturated fats, red wine (RW) drinkers have similar coronary lesion burden; calcium score however was higher compared to abstemious. Higher HDL cholesterol ascribed to RW drinking and lower plasma glucose may have protective roles.

Worsening renal function is a powerful predictor for in-hospital mortality and CV complications in ACS patients.

LV contractile reserve measured with strain imaging at low dose dobutamine echo may be used to estimate IMR as a measure of coronary microvascular function in patients without significant coronary artery disease.

The kidney function of patients undergoing diagnostic coronary angiography or PCI seems to be unrelated to the Lipid-Core Burden Index score of a non-intervened coronary artery segment.

Aspirin resistance has unfavorable effect in patients with drug eluting stents. Early or late loading of clopidogrel did not result in any difference on cardiovascular outcome among patients with drug eluting stents whether they are aspirin resistant or sensitive.

Creatinine kinase and NT-proBNP are independent predictors of 30-day risk of death or cardiogenic shock in patients with acute myocardial infarction

IL-6 at the time of coronary PCI may have short term prognostic value in pts with STEMI.

Acute myocardial infarction can be detected significantly earlier with high sensitive troponin compared to conventional troponin T.

Remarkable performance of Amulet™ in terms of efficacy and safety as reflected by the successful implantation and an absence of procedure-related complications
2 independent predictors of significant coronary artery stenosis are diabetes duration and calcium score. Flow-mediated vasodilatation and max- intima-media thickness using carotid ultrasound may also predict asymptomatic coronary artery disease more in type 2 diabetes patients.


Remarkable performance of Amulet™ in terms of efficacy and safety as reflected by the successful implantation and an absence of procedure-related complications
Significant improvement in flow mediated dilation is reported at follow-up in both patients treated with atorvastatin 40 mg and in those treated with atorvastatin 20 mg.


Remarkable performance of Amulet™ in terms of efficacy and safety as reflected by the successful implantation and an absence of procedure-related complications
Independent predictors of major bleeding are heart failure on admission, female gender, hematocrit < 36% and femoral access.


Remarkable performance of Amulet™ in terms of efficacy and safety as reflected by the successful implantation and an absence of procedure-related complications
Mean index of microcirculatory resistance is 19.8 (range 6–104); mean peak global systolic strain at rest is -17.90% and at low dose dobutamine is -21.46%, corresponding to a mean contractile reserve of + 3.6% (20% relative increase).


Remarkable performance of Amulet™ in terms of efficacy and safety as reflected by the successful implantation and an absence of procedure-related complications
A 1-fold higher incidence of contrast-induced nephropathy is shown by patients with severe hyperglycemia in comparison with those with mild hyperglycemia, while a 2-fold higher incidence of contrast-induced nephropathy is reported by patients with severe hyperglycemia in comparison with those with euglycemia and hypoglycemia.


Remarkable performance of Amulet™ in terms of efficacy and safety as reflected by the successful implantation and an absence of procedure-related complications
Significantly higher average systolic blood pressure, diastolic blood pressure, tension-time index systolic blood pressure and systolic blood pressure variability are reported in early postmenopausal women during 24-hours blood pressure monitoring than in premenopausal women.


Remarkable performance of Amulet™ in terms of efficacy and safety as reflected by the successful implantation and an absence of procedure-related complications
Long CTO lesions and tortuous vessels show only a trend for in-hospital worse outcome.


Remarkable performance of Amulet™ in terms of efficacy and safety as reflected by the successful implantation and an absence of procedure-related complications
Significantly lowest incidence of major adverse cardiac events was reported in the high-dose group. The high-dose group also significantly reported the highest compliance rate of LDL-C postoperative.


Remarkable performance of Amulet™ in terms of efficacy and safety as reflected by the successful implantation and an absence of procedure-related complications
Zero conversion rates on pump surgery are reported without nay use of an intra-aortic balloon pump. No post operative mortality or major morbidity is reported.


Remarkable performance of Amulet™ in terms of efficacy and safety as reflected by the successful implantation and an absence of procedure-related complications
The all cause 30 day mortality, MACE is similar between the no-prior PCI and prior PCI groups. Most notably, prior PCI could not be assumed as a risk factor for subsequent CABG.


Remarkable performance of Amulet™ in terms of efficacy and safety as reflected by the successful implantation and an absence of procedure-related complications
Oral anticoagulation was administered in 65% of the 149 patients in atrial flutter or atrial fibrillation. 71% among these were unaware of their target INR and 14% had no INR measurement in the 6 months prior to enrolment.

Late Breaking Reviews


Clinical assessment and improvement in Diastolic Dysfunction
Today's Spotlight


Remarkable performance of Amulet™ in terms of efficacy and safety as reflected by the successful implantation and an absence of procedure-related complications
Cardiac rehabilitation not only improves aerobic capacity but also quality of life

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