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Five year follow up results of Transplantation Of Progenitor Cells And Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI) trial A persistent improvement of LV ejection fraction was documented in 31 patients on MRI subgroup analysis. Stable LV end-systolic volume remained but significant increase in LV end-diastolic volume was reported.



Direct correlation of soluble TWEAK levels with cardiac index, reduced 6-min walk test distances and peak oxygen consumption A cutoff value of 306 pg/ml for sTWEAK was revealed on ROC curve analysis of sTWEAK levels in pulmonary artery hypertension patients as an predictive of a reduced exercise capacity (6-min walk test <300 m) with a similar predictive value in patients with pulmonary artery hypertension.



Carotid Stenting in Patients at High Surgical Risk Thirty-day death/stroke/MI rate of 2.3% was obtained with carotid artery stenting in patients at high risk for surgery



Bivalirudin Better for STEMI in Real World Setting In-hospital mortality and bleeding is lower with bivalirudin vs. heparin plus GPI in primary PCI



Early onset lone atrial Fibrillation is associated with a high prevalence of genetic variation in SCN5A and CAV3 genes encoding important components of the cardiac sodium channel 10 out of 192 patients with early-onset lone atrial fibrillation had a non-synonymous mutation in SCN5A and CAV3.



Affect of response to antiplatelet therapy during catheterization on silent cerebral infarctions In poor responders to antiplatelet therapy resulting in silent cerebral infarctions, selectively administering higher dose of antiplatelets may be useful



Affect of lifestyle interventions on hypertension in women of reproductive age Most guidelines recommended hypertension screening at least every 2 years



A greater proportion of hypertrophic cardiomyopathy patients show achievement of survival > 90 years of age than that is expected in the general population Recognition of the disease under fortuitous circumstances by detection of a heart murmur or during family screening or after onset of new symptoms showed age at hypertrophic cardiomyopathy diagnosis was 61 to 92 years (≥75 years in 21).



Vector Velocity Imaging shows significantly decreased myocardial function in both single left and right ventricles when compared to normal hearts Compared to normal hearts depressed longitudinal velocity, strain and strain rate were reported in all study patients.



EFFICAS II study: Comparison of the procedure duration, RF ablation time, numbers of ablations for pulmonary vein isolation and fluoroscopy time between EFFICAS I and EFFICAS II 42% of 2060 ablations in EFFICAS I were performed with an FTI < 400 gs as compared to 18% of 1860 ablations applied in EFFICAS II



Breath-based lipid test study reveals strong correlations between measured and predicted values during both lipid suppression and lipid infusion studies Measured and predicted triglycerides and free fatty acids values also displayed very strong statistical agreement in this most accurate common prediction model.



PREDICT study: coronary artery calcium correlated with gene expression score significantly in the coronary artery calcium cohort Positive correlation was shown between increasing gene expression score and CT coronary angiography -defined maximum stenosis as previously seen for invasive angiography.



Familial Atherosclerosis Treatment Study-Observational Study (FATS-OS): CIMT is statistically no longer a sensitive marker for tracking atherosclerosis change in prolonged intensively treated population A minimum of 1239 subjects are required for the further statistical power analysis so as to be able to detect 0.01 mm difference over time. 2478 subjects are required for the detection of 0.01 mm difference among the 2 treatment groups.



Analysis of the left atrium by a recently proposed technique for 3D shape indexes and description of its changes during the cardiac cycle A significant cyclic behavior was shown by all left atrium shape indexes (median; 25%-75%, p<0.03 for all,) but with different amplitude changes which were maximal for sphericity (12%) and minimal for ellipticity (3%).



Trastuzumab -induced cardiotoxicity in patients with breast cancer followed for a 3-month period of treatment None of patients had symptomatic heart failure at 3 months though impaired ventricular relaxation with a significant increase in E/e' ratio was developed in 19.4% patients.



Echocardiographic Heart of England Screening (ECHOES) study: A 10-year survival of 11.6% shown by multiple-cause heart failure Ten-year survival for participants without HF, for those with HF, for those with LVSD and for those with HF and LVSD were 75%, 26.7%, 37.6%, and 27.4% respectively.



Variable in-hospital cardiac arrest events often linked with lower hospital quality of care In a multivariable regression model, case-mix adjusted IHCA event rates were highest in urban hospitals and hospitals with higher proportions of black patients and lower in larger hospitals.



Possibility of a reduced valve opening due to low cardiac output in patients with significant aortic stenosis All patients reported increased cardiac output was reported during dobutamine stress.



3D dyssynchrony after cardiac resynchronization therapy implant identifies a cohort who may derive greater benefit from cardiac resynchronization therapy optimization Optimization in 11 patients with a post cardiac resynchronization therapy systolic dyssynchrony index of >10 led to a 10.8% relative increase in ejection fraction.



Efficacy of post-operative intravenous landiolol therapy followed by oral carvedilol Postoperative atrial fibrillation occurred in 4 of the 36 patients in the landiolol group as compared with 11 of the 34 patients in the control group.



Effect of statins on exercise-induced muscle injury Susceptibility to exercise-induced muscle injury with statins increases with age



Correlation between Platelet Reactivity to Adenosine Diphosphate before DES Implantation and outcomes in Patients with Stable Angina Of the adverse ischemic events occurring at one year, target lesion revascularization was identified as the main event.



Additional benefit of flavonoids to standard drug therapy in managing CVD risk in postmenopausal type 2 diabetic patients The combined flavonoid intervention resulted in a significant reduction in estimated peripheral insulin resistance and improvement in insulin sensitivity.



SCAAR: Clinical outcomes of everolimus eluting platinum chromium stent in unselected patient population Promus Element stent appears is associated with low risk of restenosis and stent thrombosis



Non-sudden cardiac death risk an important issue in patient selection for prophylactic ICD therapy Patients at high risk of non-sudden cardiac death do not gain significant survival benefit from prophylactic implantable cardioverter defibrillator therapy irrespective of their risk of sudden cardiac death.



Sensitive diagnostic tools for the early identification of abnormal LV-arterial coupling Patients with lower longitudinal strain (< 13.5 %) showed a significantly increased beta when compared with subjects with greater longitudinal strain (> 13.5 %).



Meta-analysis of the AortaGen Consortium: Locus on chromosome 14 identified in the 3'-BCL11B gene desert associated with an increased risk for coronary artery disease and heart failure Consistent results were observed in younger (6 cohorts; N=13,914) and older (9 cohorts; N=12,026) participants.



Higher efficacy of the combination of robotic therapy + conventional therapy vs. conventional therapy alone in non-ambulant participants after sub-acute stroke More improvement at follow-up was reported in the low motricity robotic group than the control group with regards to functional ambulation category, Barthel Index and Rivermead Mobility Index whereas the effectiveness of conventional and robotic therapies was equal in the high motricity groups



The LOD-DIABETES study: An increase in antihypertensive drug use is the variable that best predicts a decrease in pulse wave velocity in subjects with metabolic syndrome Patients with metabolic syndrome showed an increase in HDL-cholesterol, fibrinogen, Cornell voltage-duration product, ankle/brachial index and the use of antihypertensive and lipid-lowering drugs and a reduction in serum glucose, HOMA, systolic, diastolic blood pressure and pulse wave velocity



Azelnidipine and amlodipine on Glucose tolerance and ENdothelial function crossover Trial (AGENT): significantly decreased heart rate after azelnidipine administration than that after amlodipine administration Significantly decreased levels of glucose and insulin 120 min were reported due to azelnidipine after 75 g OGTT as compared with amlodipine administration.



3 g cinnamon does not alter the postprandial response to a high-fat test meal Gastric emptying parameters, postprandial triacylglycerol or glucose concentrations, oxidative stress, arterial function or appetite were unaffected by cinnamon.



Confirmatory factor analysis of a single-factor-model for validation of metabolic syndrome index over 6-years Good fit indexes for the change are displayed by the construct stability of supporting the hypothesis of a single factor underlying metabolic syndrome component trends.



PERISCOPE trial: cardiovascular disease progression is more in patients with longer diabetes duration Disease progression slowed by an intensive control of LDL-C below 100mg/d but this efficacy was attenuated in patients with longer diabetes duration.



Non homogenous impact of hyperglycemia in different age-groups of patients with acute myocardial infarction Significantly higher areas under the ROC curves was reported in age group <50 years.



Smaller whole and regional brain volumes among patients who undergo Blalock-Taussig shunt Significantly reduced whole and frontal lobe volumes were reported in infants with congenital heart defects with transposition of the great arteries or single ventricle physiology at around one year old when compared with normal controls.



Multivessel PCI patients compared to multivessel CABG patients are 3 times more likely be discharged Fewer complications are reported by multivessel PCI as compared to mCABG and 30% lower chance of complications was independently associated with it.



Effect of modifying transcatheter aortic valve replacement strategy on regurgitation Modified transapical transcatheter aortic valve replacement technique minimizes paravalvular regurgitation



Influence of pulmonary artery pressure on the curvature of the interventricular septum measured by ECG-gated conventional scanning with 320-slice computed tomography in subjects with chronic thrombo-embolic pulmonary hypertension The correlation coefficient of septal curvature with sPAP was -0.74 and mPAP was -0.81.



Transient cardiac arrest with administration of adenosine for Valvuloplasty in Patients Undergoing Transcatheter Aortic Valve Implantation Occurrence of ventricular ectopic contractions triggered by balloon inflation and deflations, accounts for balloon displacement and crossover to rapid right ventricular pacing



Association of discharge heart rate with mortality in AMI patients treated with primary percutaneous coronary intervention Every increase of 5 b.p.m. in heart rate at discharge results in 29% increased risk of cardiovascular mortality at 1year and 24% increased risk at 4-year follow-up period



Late adverse events associated with the use of sirolimus-eluting stent - a first-generation drug-eluting stents Stent Thrombosis, TLR persist at low levels upto 5 years with First-Gen DES



Well-controlled HIV infection is not an independent risk factor for blunted myocardial glucose utilization per unit of insulin Myocardial glucose utilization when normalized to fasting plasma insulin concentration (GLUT/INS) was lower in men with metabolic complications than in men without metabolic complications.



Patients with IHD3 with coronary 1 vessel have impaired frequency of marrow-derived circulating progenitor cells Patients with IHD3 reported impaired frequency of BM-CPCs when compared to IHD1 (CD34/45⁺).) and IHD2 (CD34/45⁺).



Correlations between soluble ST2 levels and HbA1c in type 2 diabetics with and without left ventricular diastolic dysfunction HbA1c positively and independently correlated with soluble ST2 levels in patients with type 2 diabetes with and without left ventricular diastolic dysfunction on multivariate analysis.



Malmo Preventive Project Re-examination Study: older women than older men show more pronounced risk factor clustering and worse self-rated health with increased glucometabolic disturbance Significantly steeper slope of the trend curve with increasing CVD risk factor burden was observed for older women than for older men.